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3M™ Zeta Plus™ LA Series Filter Cartridge

3M ID B40070856
  • Designed to have the lowest organic and inorganic extractable levels in the 3M depth filter portfolio
  • Stringent product extractable specifications are enabled by pre-extraction of both cellulose fiber and filter aid
  • Reduced potential of 1,3 beta-glucan interference in product endotoxin testing based on the use of aggressively extracted cellulose fibers
  • Filtration performance optimized to a broad range of fluid challenges
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Product Details
  • Designed to have the lowest organic and inorganic extractable levels in the 3M depth filter portfolio
  • Stringent product extractable specifications are enabled by pre-extraction of both cellulose fiber and filter aid
  • Reduced potential of 1,3 beta-glucan interference in product endotoxin testing based on the use of aggressively extracted cellulose fibers
  • Filtration performance optimized to a broad range of fluid challenges
  • Full range of scalable filters enables predictable performance at every stage of drug development from early stage discovery to commercial production
  • Full range of scalable capsule and cartridge filter configurations allow for pilot testing and scale-up using the same materials as with full-scale systems

We designed Zeta Plus™ LA Series Filter Cartridges for pharmaceutical manufacturing applications where the most stringent organic and inorganic extractables requirements exist. The cartridges have a reduced potential for yielding false positives in product endotoxin testing resulting from 1,3 beta-glucan interference in LAL (Endotoxin) assays due to aggressive extraction of the cellulose fibers

Zeta Plus™ LA Series filter media is a mixture of high surface area, inorganic particles, cellulose, and a positively charged crosslinking polymer. These filters are designed for the lowest organic and inorganic extractable levels of the 3M depth filter portfolio by aggressively extracting both the inorganic particles and cellulose fibers. The combination of filtration efficiency and throughput results from the balance between porosity, depth, and the relatively low level anion exchange capacity: removing some negatively charged soluble contaminants and sub-micronic particles through anion exchange, and larger particles by mechanical sieving. Zeta Plus™ LA Series Filter Cartridges are constructed from multiple lenticular cells of opposing media disks that are bonded together with molded edge seals, assembled with polypropylene seals between each cell, and then unitized with stainless steel bands. Cartridges and sanitary housings are available in 8", 12", and 16" diameter formats, which enable predictable scale-up to full scale production. Pharmaceutical Grade The Zeta Plus™ LA Series Filter Cartridges are specifically designed for use in the manufacture of biopharmaceutical, vaccine, blood fractionation and small molecule API drug substances. The effluent characteristics of the Zeta Plus LA Series Filter media has been tested following a number of protocols contained in the United States Pharmacopeia (USP) compendia. The Zeta Plus LA Series filter media is specifically designed to have the lowest organic and inorganic extractable levels of the entire 3M depth filter portfolio. Stringent product extractable specifications are controlled, in part, by aggressively extracting both the cellulose fibers and filter aids prior to producing the filtration media. Due to the pre-extraction of the cellulose fibers, the LA Series filtration media has a reduced potential of yielding false positives in product endotoxin testing resulting from 1,3 beta-glucan i

Suggested Applications

  • Use for the clarification of bioprocess, biological and pharmaceutical fluids
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