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  • Zeta Plus™ Encapsulated System Scale-Up Filter Capsule with DEL Series Media
  • Zeta Plus™ Encapsulated System Scale-Up Filter Capsule with DEL Series Media

    3M ID B40066803
    • Self-contained, single-use capsules are available in three convenient sizes of 170, 340, and 1020 cm2 for scale-up and benchtop studies
    • Stackable Scale-Up Capsules are designed with three feet and rubber shoes for a level posture on many surfaces
    • Two different media formulations provide efficient reduction of undesirable lipids, lipoprotein haze, and microbial and particulate contaminants
    • Low hold-up volume for minimal fluid loss and novel shape to maintain the same lenticular flow path as larger capsules and cartridges
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    Product Details
    • Self-contained, single-use capsules are available in three convenient sizes of 170, 340, and 1020 cm2 for scale-up and benchtop studies
    • Stackable Scale-Up Capsules are designed with three feet and rubber shoes for a level posture on many surfaces
    • Two different media formulations provide efficient reduction of undesirable lipids, lipoprotein haze, and microbial and particulate contaminants
    • Low hold-up volume for minimal fluid loss and novel shape to maintain the same lenticular flow path as larger capsules and cartridges
    • FDA Drug Master File and USP Class VI Biological Reactivity Tests eases validation and regulatory submissions.

    We designed the Zeta Plus™ Encapsulated System Scale-Up Filter Capsules with DEL Media as single-use depth filtration capsules for the life sciences industry. The capsules feature two choices of depth filter media, DELI and DELP, for selective reduction of lipids, surfactants and biological hydrophobes from human blood plasma, serum-based products, and other biological fluids.

    During protein purification processes, lipid contamination can cause an assortment of processing problems like fouling of expensive chromatography columns and membrane filters. Lipid contamination can also cause solution instability of intermediate and final protein products leading to a problematic lipoprotein haze. Our Zeta Plus™ DEL series media can be used to reduce lipids in the following lipid classes: mono-, di-, and triglycerides, fatty acids, cholesterol, phospholipids, and lipoproteins. Reduction of lipid contaminants from protein solutions can be highly desirable, potentially leading to improved processing economies (extended column and membrane life), improved product purity, and enhanced final protein product stability. Zeta Plus Scale-Up Filter Capsules with DEL Media are manufactured to controls described in our Drug Master File on record with the FDA, and Certificates of Quality are included with every filter. Our Zeta Plus™ DEL Series filter media is unique in that we incorporate silica adsorbents into our media work as the active components for lipid reduction. We offer two different types of Zeta Plus DEL Series filter media to suit your various application requirements. We differentiate the DEL Series media offerings by varying the materials of construction used in manufacturing. Choice of silica type creates either a medium or a high capacity for lipids, based upon the specific surface area (g/m²) of the silica used in the filter matrix. Zeta Plus Scale-Up Filter Capsules with DEL Series Media are highly scalable and can be used for applications ranging from small laboratory volumes to production-scale operations. The Zeta Plus Encapsulated System includes capsule filters with effective filtration areas of 170 cm², 340 cm², and 1020 cm² and the capsules have been designed for minimal hold-up volume. They also incorporate 3 feet and rubber shoes for a level posture on many surfaces and can be stacked for convenience. Encapsulating

    Suggested Applications

    • Use for lipid reduction from human blood plasma proteins such as albumin, coagulation factors, fibrinogen, and immunoglobulins
    • Use to provide protection, enhanced performance, and extended life for chromatography columns and ultrafiltration filters

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