Single-use technology is a cost-efficient option to increase biomass production in therapeutic recombinant protein processes across a wide range of operating conditions.
3M™ Polisher ST can be used to replace downstream AEX polishing columns in both batch and continuous processes. It features:
This technology provides a compact, small footprint solution. It has a high capacity and can deliver greater purity and yield in the polishing step of the downstream process.
3M Polisher ST allows a facility strategy that can overcome scale limitations and enable cost-efficient manufacturing, to support the growing demand for biologics. It can be deployed in a batch process or as part of a connected continuous downstream process for the flexible facility of the future.
3M Polisher ST is a fully encapsulated single-use anion exchange (AEX) membrane adsorber product. It is designed for the downstream processing of monoclonal antibodies (mAbs) and other recombinant proteins in flow-through mode. The product is intended to reduce host cell proteins (HCPs), viruses and other negatively charged contaminants as part of the polishing chromatography purification of biopharmaceutical process streams.
This synthetic membrane adsorber contains two complementary AEX-functional medias:
3M Polisher ST is designed to improve monoclonal antibody development and manufacturing processes in a wide range of polishing process conditions.
Are you interested in replacing your downstream AEX polishing column with a single-use AEX membrane adsorber? Learn how to set up experiments for implementing 3M Polisher ST in your downstream process. Sign up for a virtual trial with a 3M application engineer.
3M aims to support you in the development of more efficient bioprocesses. Chromatographic clarification of cell culture fluid using the 3M Emphaze AEX Hybrid Purifier enables the early removal of soluble impurities such as HCP, DNA and endotoxins, which allows the downstream unit operations to perform better. The newest solution, 3M Polisher ST, is a single-use, membrane adsorber purification solution designed for the downstream processing of monoclonal antibodies (mAbs) and other recombinant proteins in flow-through mode. 3M Polisher ST is designed to improve monoclonal antibody (mAb) development and manufacturing processes in a wide range of polishing process conditions. These solutions enable elimination and/or reduction in size of unit operations, leading to better overall process economics.
These process trains illustrate how 3M products work together to create solutions that simplify the purification process and eliminate process steps.
Single-use, encapsulated devices for the removal of cell mass with low cell shear. Wide selection of grades and two charge levels for small particle removal and membrane filter protection.
Single-use, encapsulated devices for the removal of cell mass with low cell shear. Wide selection of grades and two charge levels for small particle removal and membrane filter protection.
Synthetic, single-use chromatographic clarification device. Delivers consistent, high-purity clarified process fluid by providing flow-through chromatographic separation of negatively charged HCP, DNA and endotoxins.
Synthetic, single-use chromatographic clarification device. Delivers consistent, high-purity clarified process fluid by providing flow-through chromatographic separation of negatively charged HCP, DNA and endotoxins.
Are you interested in replacing your downstream AEX polishing column with a single-use AEX membrane adsorber? Learn how to set up experiments for implementing 3M Polisher ST in your downstream process. Sign up for a virtual trial with a 3M application engineer.
Explore publications from industry experts to learn about the latest innovations and emerging trends in biotech and bioprocessing.
Read an analysis by F&S of 3M Polisher ST technology when used to replace depth filtration and anion exchange chromatography (AEX) steps and how it achieves a simplified and cost effective process across a wide range of conditions.
Read a F&S analysis of 3M Polisher ST performance across scales on virus clearance under a wide range of process conditions.
Review a Frost & Sullivan infographic to see how 3M Polisher ST can help you transition your anion exchange (AEX) chromatography to a single-use solution with advanced AEX technology.
BioProcess International introduces 3M Polisher ST. See how it can streamline polishing and viral clearance.
The goal of new bioprocessing strategies is to increase the biopharmaceutical process robustness and to reduce cost. Here we explore the effects of implementing such new strategies, enabled by novel 3M solutions, on the cost of mAb manufacturing process using modelling. Specifically, we look at the implementation of the 3M Polisher ST AEX polishing solution.
Single-use anion exchange (AEX) chromatography solution intended to replace the reusable AEX polishing column for biologic drug manufacturing.
Learn about novel bioprocessing technologies in the biomanufacturing space that are in development for existing downstream processes.
Join us as we explore how novel bioprocessing solutions, based on advanced materials and ligand chemistries, enable new bioprocessing strategies that address critical challenges in process simplification and intensification. Specifically, we demonstrate how implementing chromatographic separation at clarification enables single stage, scalable, and efficient harvesting unit operation. Additionally, we show that a combination of novel ligand chemistry and non-woven support technologies, enable effective transition of the polisher AEX unit operation to a single use solution, using 3M Polisher ST.
A compact, small footprint solution with higher capacity, delivering greater purity and yield downstream.
Find the detail and technical data for 3M Polisher ST.
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