Technician sets up compact single-use polishing AEX membrane adsorber.

Single-use anion exchange chromatography

Single-use technology is a cost-efficient option to increase biomass production in therapeutic recombinant protein processes across a wide range of operating conditions.

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A cost-efficient, compact solution

  • 3M Polisher ST purifier containing a quaternary ammonium functional nonwoven and a guanidinium functional membrane.

    3M™ Polisher ST

    3M™ Polisher ST can be used to replace downstream AEX polishing columns in both batch and continuous processes. It features:
     

      • 100x mAb loading of typical Q resin (10+ kg/m² target loading)
      • Scalability from lab to manufacturing scale
      • High salt and low pH tolerance
      • Robust viral clearance across very wide range of conditions

      This technology provides a compact, small footprint solution. It has a high capacity and can deliver greater purity and yield in the polishing step of the downstream process.

      3M Polisher ST allows a facility strategy that can overcome scale limitations and enable cost-efficient manufacturing, to support the growing demand for biologics. It can be deployed in a batch process or as part of a connected continuous downstream process for the flexible facility of the future.

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    3M Polisher ST is a fully encapsulated single-use anion exchange (AEX) membrane adsorber product. It is designed for the downstream processing of monoclonal antibodies (mAbs) and other recombinant proteins in flow-through mode. The product is intended to reduce host cell proteins (HCPs), viruses and other negatively charged contaminants as part of the polishing chromatography purification of biopharmaceutical process streams.

    This synthetic membrane adsorber contains two complementary AEX-functional medias:
     

    • A quaternary ammonium (“Q”) functional nonwoven which provides reduction of turbidity, DNA and endotoxin. It also may provide HCP and virus reduction depending on fluid conditions.
    • A guanidinium-functional membrane which is salt and pH tolerant and provides high HCP and virus reduction performance in a wider range of conditions compared to conventional Q-functional AEX resins. The novel guanidinium functionality of the downstream AEX polishing membrane mimics the amino acid arginine, one of the three positively charged naturally occurring standard amino acids that make up proteins.

    3M Polisher ST is designed to improve monoclonal antibody development and manufacturing processes in a wide range of polishing process conditions.


Sign up for a virtual trial of 3M Polisher ST

Are you interested in replacing your downstream AEX polishing column with a single-use AEX membrane adsorber? Learn how to set up experiments for implementing 3M Polisher ST in your downstream process. Sign up for a virtual trial with a 3M application engineer.


Bioprocessing reimagined

3M aims to support you in the development of more efficient bioprocesses. Chromatographic clarification of cell culture fluid using the 3M Emphaze AEX Hybrid Purifier enables the early removal of soluble impurities such as HCP, DNA and endotoxins, which allows the downstream unit operations to perform better. The newest solution, 3M Polisher ST, is a single-use, membrane adsorber purification solution designed for the downstream processing of monoclonal antibodies (mAbs) and other recombinant proteins in flow-through mode. 3M Polisher ST is designed to improve monoclonal antibody (mAb) development and manufacturing processes in a wide range of polishing process conditions. These solutions enable elimination and/or reduction in size of unit operations, leading to better overall process economics.

These process trains illustrate how 3M products work together to create solutions that simplify the purification process and eliminate process steps.

3M Solutions

  • Biopharma process train showing 3M products
Eliminate the centrifuge

The combination of 3M™ Zeta Plus™ Series Depth Filter, 3M™ Emphaze™ AEX Hybrid Purifier and 3M™ LifeASSURE™ Membrane Filters may be a compelling alternative to a centrifuge-based Harvest-Clarification process.

Want to learn more? Check out this article.

Comprehensive options

Single-use, encapsulated devices for the removal of cell mass with low cell shear. Wide selection of grades and two charge levels for small particle removal and membrane filter protection.

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Simplify the process

Synthetic, single-use chromatographic clarification device. Delivers consistent, high-purity clarified process fluid by providing flow-through chromatographic separation of negatively charged HCP, DNA and endotoxins.

Download data sheet (PDF, 395 KB)

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Quality and reliable

3M™ Emphaze™ AEX Hybrid Purifier enables use of a smaller 3M™ LifeASSURE™ PDA filter capsule and/or tighter grade membrane for more consistent bioburden control and higher product recovery.

View all products

Cost-efficient and compact

3M Polisher ST is a fully encapsulated single-use anion exchange (AEX) product intended to reduce host cell protein impurities, viruses, and other negatively charged contaminants in flow-through polishing chromatography.

View all products

3M™ Polisher ST

  • Biopharma process train showing 3M products
 
 
Cost-efficient and compact

3M Polisher ST is a fully encapsulated single-use anion exchange (AEX) product intended to reduce host cell protein impurities, viruses, and other negatively charged contaminants in flow-through polishing chromatography.

View all products


Book your virtual trial of 3M Polisher ST

Are you interested in replacing your downstream AEX polishing column with a single-use AEX membrane adsorber? Learn how to set up experiments for implementing 3M Polisher ST in your downstream process. Sign up for a virtual trial with a 3M application engineer.


Industry insights

Explore publications from industry experts to learn about the latest innovations and emerging trends in biotech and bioprocessing.

  • The goal of new bioprocessing strategies is to increase the biopharmaceutical process robustness and to reduce cost. Here we explore the effects of implementing such new strategies, enabled by novel 3M solutions, on the cost of mAb manufacturing process using modelling. Specifically, we look at the implementation of the 3M Polisher ST AEX polishing solution.

  • Single-use anion exchange (AEX) chromatography solution intended to replace the reusable AEX polishing column for biologic drug manufacturing.

  • Learn about novel bioprocessing technologies in the biomanufacturing space that are in development for existing downstream processes.

  • Watch the webinar
    Watch the webinar: Learn how 3M solutions can enable new bioprocess simplification and intensification strategies

    Join us as we explore how novel bioprocessing solutions, based on advanced materials and ligand chemistries, enable new bioprocessing strategies that address critical challenges in process simplification and intensification. Specifically, we demonstrate how implementing chromatographic separation at clarification enables single stage, scalable, and efficient harvesting unit operation. Additionally, we show that a combination of novel ligand chemistry and non-woven support technologies, enable effective transition of the polisher AEX unit operation to a single use solution, using 3M Polisher ST.


Video library


Designed for the flexible facility of the future

A compact, small footprint solution with higher capacity, delivering greater purity and yield downstream.

  • Older solutions for AEX polishing columns requiring a much larger footprint.
    Competitor:
  • 3M Polisher ST is compact, small footprint solution.
    3M Polisher ST:

Register now for a virtual trial of 3M Polisher ST

Are you interested in replacing your downstream AEX polishing column with a single-use AEX membrane adsorber? Learn how to set up experiments for implementing 3M Polisher ST in your downstream process. Sign up for a virtual trial with a 3M application engineer.
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